Adzenys vs. Adderall: How Do They Differ?
Medically reviewed by Femi Aremu, PharmDMedically reviewed by Femi Aremu, PharmDAdzenys and Adderall are prescription medications commonly taken to treat attention deficit hyperactivity disorder (ADHD). Both drugs are stimulant-based and work by increasing the levels of certain neurotransmitters in the brain. The targeted neurotransmitters help improve focus, attention, and impulse control.Despite their similar purposes, Adzenys and Adderall differ in their formulations, how they're administered, and how they are released in the body. Understanding these differences and similarities can help make informed decisions about ADHD treatment options that meet one’s individual needs.
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Adzenys
Adderall
Uses
ADHD
ADHD
Administration
Orally disintegrating tablet (ODT) may be taken without water, with or without food
Capsules can be sprinkled onto food for those who have difficulty swallowing pills. Tablets may be cut or split.
Dosage forms
Available as an extended-release ODT
Available as extended-release capsules and immediate release tablets.
Onset of action
45 to 60 minutes
Within an hour
Duration of action
Up to 12 hours
Up to 12 hours (4 to 6 hours or immediate-release formulation)
Strengths
Available in 3.1 milligrams (mg), 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, and 18.8 mg tablets.
Extended-release capsules available in 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg. Immediate-release tablets available in 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, and 30 mg.
What Is Adzenys?Adzenys is taken to treat ADHD in both children and adults. Its main ingredient is the stimulant amphetamine. By boosting levels of neurotransmitters like dopamine and norepinephrine, Adzenys helps improve focus, attention, and behavior in individuals with ADHD.Adzenys offers several benefits for individuals with ADHD, including flexible dosing options. One key advantage is its extended-release formulation, which provides a consistent therapeutic effect throughout the day, reducing the need for multiple doses. The orally disintegrating tablet (ODT) form is also convenient for those who have difficulty swallowing pills because it dissolves easily on the tongue without water.Adzenys has the same clinical efficacy as other mixed amphetamine extended-release formulations at equivalent doses. It also shares similar safety and tolerability characteristics.Uses of AdzenysAdzenys is primarily taken to treat ADHD in both children and adults. The U.S. Food and Drug Administration (FDA) has approved it for this specific purpose. It also helps to manage symptoms like inattention, hyperactivity, and impulsivity.Side Effects of AdzenysAdzenys can cause side effects that vary from person to person. Common side effects include:NauseaVomiting FatigueTrouble sleeping Decreased appetiteDry mouthIncreased heart rate or blood pressureSome may also experience headaches, nervousness, or irritability.Most side effects are mild and manageable. However, it’s important to be aware of more serious risks, such as heart problems or mental health changes like mood swings or anxiety.If you experience any concerning symptoms, talk to your healthcare provider. They can help adjust your dosage or explore other treatment options.What Is Adderall?Like Adzenys, Adderall is commonly taken to treat ADHDy It contains a combination of amphetamine and dextroamphetamine, which are stimulant drugs that affect chemicals in the brain related to focus, attention, and impulse control. Adderall works by increasing the levels of neurotransmitters like dopamine and norepinephrine, helping to improve concentration and reduce hyperactive and impulsive behaviors.Adderall is highly effective at improving ADHD symptoms. Unlike Adzenys, it is available in both immediate-release and extended-release forms, which offers flexibility in managing symptoms throughout the day.Uses of AdderallSimilar to Adzenys, Adderall is also approved by the FDA to treat ADHD in children and adults.Side Effects of AdderallAdderall can cause side effects that vary in severity. Common side effects include:DizzinessNauseaDifficulty sleepingLoss of appetiteDry mouthIncreased heart rate or blood pressure In rare cases, Adderall may lead to more serious effects, such as heart-related issues, mood changes, or increased anxiety. Monitor yourself for any unusual symptoms and discuss them with your healthcare provider.Safety PrecautionsAdzenys and Adderall are both controlled substances, which means they have a high potential for abuse that can lead to dependencies. In light of this, healthcare providers more strictly regulate them to ensure they are taken safely and appropriately.Certain groups may be at a higher risk of experiencing side effects when taking Adderall or Adzenys including those with:Heart conditions, such as hypertension, heart disease, or arrhythmiasHistory of anxiety, depression, or other mental health conditionsHistory of substance abuseMedication appropriateness should be evaluated individually and addressed by the healthcare provider to ensure safety.Drug InteractionsAdzenys and Adderall have the potential to interact with:Selective serotonin reuptake inhibitors (SSRIs) such as Lexapro (escitalopram) and Prozac (fluoxetine)Serotonin-norepinephrine reuptake inhibitors (SNRIs) such as Cymbalta (duloxetine) and Effexor (venlafaxine)Monoamine oxidase inhibitors (MAOIs) such as Nardil (phenelzine)Pain medications containing tramadolSome medications for weight loss contain phentermine or topiramateLimit caffeine and alcohol intake while taking either medication because these substances may worsen adverse effects.Special ConsiderationsPatients taking Adderall XR may be switched to Adzenys XR at an equivalent dose taken once daily. Adzenys 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, and 18.8 mg tablets are equivalent to 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg of Adderall XR, respectively.When switching from other amphetamine-containing products, discontinuation of treatment followed by slow titration with Adzenys XR-ODT is recommended.Adderall dose adjustment is necessary in those with reduced kidney function. There are risks associated with the use of Adderall and Adzenys during pregnancy. You should discuss them with your healthcare provider.SummaryAdzenys and Adderall are both stimulant medications taken to manage ADHD. They treat similar conditions but have distinct differences in their formulations. The ODT formulation of Adzenys allows the medication to dissolve on the tongue. This provides a steady drug release of the drug throughout the day, easier administration, and consistent symptom management. Adderall’s immediate-release form provides quicker onset relief, while its extended-release version offers prolonged symptom control. Both medications require careful monitoring for potential side effects and interactions. Consider whether a long-acting or immediate-release formulation is more appropriate when choosing a medication. Read the original article on Verywell Health.
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