Rosie O’Donnell Shows Off Dramatic Weight Loss After Using Mounjaro
:max_bytes(150000):strip_icc():focal(725x199:727x201):format(webp)/Rosie-O-Donnell-052425-tout-97ffbfdcda114d4ea2557183162934fe.jpg)
The comedian has been on a journey to improve her health for several years, and shared two years ago that her doctor had put her on Mounjaro and Repatha
By Kimberlee Speakman
Kimberlee Speakman profile headshot.
Kimberlee Speakman
Kimberlee Speakman is a digital writer at PEOPLE. She has been working at PEOPLE since 2022. She has also worked in broadcast television as a reporter for Hawaii-based news station KHON2 News.
People Editorial Guidelines
Published on May 24, 2025 06:38PM EDT
Comments
Rosie O Donnell
Rosie O'Donnell.
Credit : Emma McIntyre/Getty;Rosie O Donnell/Instagram
NEED TO KNOW
Rosie O’Donnell showed off her new slimmer body in an Instagram photo on May 23
"I can't believe this is me now," the comedian wrote
She revealed in January 2023 that her doctor had put her on Mounjaro and Repatha and that she had been making lifestyle changes like cutting out sugar
Rosie O’Donnell is sharing how she feels about her recent weight loss.
The View alum, 63, showed off her new, slender figure — which was at least partly attributed to Mounjaro, a popular drug that several celebrities have used to slim down — in an Instagram post on Friday, May 23.
She shared a screenshot of a recent video taken of herself onstage. She could be seen wearing dark pants and a light green sweater as she held a mic and a mic stand while appearing to talk to the audience.
“I can't believe this is me now,” she captioned the photo. She also added the hashtags “#mounjaro,”#weightloss” and “#bodydismorphia.”
Mounjaro (tirzepatide) is a medication for type 2 diabetes and weight loss — similar to Ozempic and Wegovy — taken weekly by injection in the thigh, stomach or arm. Several famous figures, including Elon Musk, Meghan Trainor and her husband Daryl Sabara, and Kyle Richards’ 25-year-old daughter Sophia Umansky, have shared in recent months that they have used the drug.
O'Donnell, who moved to Ireland a few months ago with her 12-year-old child Clay, gave fans an update on her weight loss journey in a TikTok video in March.
Never miss a story — sign up for PEOPLE's free daily newsletter to stay up-to-date on the best of what PEOPLE has to offer, from celebrity news to compelling human interest stories.
Rosie O'Donnell and Carolyn Strauss attend Sky's UK Premiere of "The Last of Us" Season II at Vue West End on April 10, 2025 in London, England.
Rosie O'Donnell in April 2025.
Mike Marsland/Getty
“I’ve lost more weight. I am on Mounjaro for my diabetes and one of the side effects is you lose weight," she said. "But it’s also because I had a chef for over two years in Los Angeles and I don't have a chef now. It's me cooking for Clay and me.”
The comedian said at the time that she had to go shopping in Dublin to get new clothes that “fit better” after her weight loss. She also reflected on how she felt about the change after struggling with her weight for several years.
"I'm one of those people who always had a weight issue and now that I'm a size large — instead of an XL or a XXL — I find it shocking," she said. "I really do. I find it completely shocking."
Related Stories
Rosie O’Donnell Reveals in New Doc How a Service Dog Helped 'Save' Her Autistic Child (Exclusive)
Rosie O’Donnell Shares How Enlisting Service Dog Helped ‘Save My Kid’ After Autism Diagnosis in New Doc Unleashing Hope
Rosie O'Donnell Opens Up About Whether She Has Any Regrets About Leaving the U.S. for Ireland
Rosie O'Donnell
In January 2023, O’Donnell shared that her doctor had put her on Mounjaro and Repatha two months prior and she'd already started seeing a difference. She explained, "One I do every other week and one I do once a week."
In addition to taking medication, The Flintstones star has also made some lifestyle changes. She shared at the time that she’s “not eating sugar as much as I can” and has been more focused on drinking water.
“My appetite has decreased significantly. It's probably the meds. And I'm trying to move more. So, all those things combined, that's what it is," she said at the time.
Welcome to Billionaire Club Co LLC, your gateway to a brand-new social media experience! Sign up today and dive into over 10,000 fresh daily articles and videos curated just for your enjoyment. Enjoy the ad free experience, unlimited content interactions, and get that coveted blue check verification—all for just $1 a month!
Account Frozen
Your account is frozen. You can still view content but cannot interact with it.
Please go to your settings to update your account status.
Open Profile Settings